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These types of reminders are now used in addition to phone calls and letters.

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Depending on the disease, some untreated STIs can lead to infertility, chronic pain or even death.

Some of these microbes are known to be sexually transmitted.

Many STIs are (more easily) transmitted through the mucous membranes of the penis, vulva, rectum, urinary tract and (less often—depending on type of infection) the mouth, throat, respiratory tract and eyes.

Specific age groups, persons who participate in risky sexual behavior, or those have certain health conditions may require screening.

The CDC recommends that sexually active women under the age of 25 and those over 25 at risk should be screened for chlamydia and gonorrhea yearly.In the case of HIV, sexual transmission routes almost always involve the penis, as HIV cannot spread through unbroken skin; therefore, properly shielding the penis with a properly worn condom from the vagina or anus effectively stops HIV transmission.